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  • 产品名称：anti-CD40antibody(CD40Molecule,TNFReceptorSuperfamilyMember5)(FITC)

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  • 产品厂商：Acris-antibodies
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简单介绍：
anti-CD40antibody(CD40Molecule,TNFReceptorSuperfamilyMember5)(FITC)
详情介绍：
Clone 1C10
Isotype IgG2a
Specificity This antibody is specific to Mouse CD40 (Mr. 45-50 kDa)
Characteristics Synonyms: TNFRSF5, CDw40, Bp50, Tumor necrosis factor receptor superfamily member 5, B-cellsurface antigen CD40, CD40L receptor
Alternative Name CD40 (CD40 Antibody Abstract)
Background CD40 is a type I cell surface protein belonging to the tumor necrosis factor superfamily of cell surface receptors. In mice it is expressed on B lineage cells, follicular dendritic cells, thymic epithelium, and interdigitating cells in the T-cell zone of secondary lymphoid organs. (Ref.1-5) CD40 first becomes detectable on a subset of small pre-B II cells in bone marrow, with the levels of CD40 expression increasing thereafter during B-cell maturation. Immature B cells (IgM+IgDloB220lo) express intermediate levels of CD40, whereas mature B cells (IgM+IgDhiB220hi) express high levels. (Ref.4) CD40 has a central role in B cell growth and differentiation, and signalling through CD40 in combination with IL-4 reportedly induces immunoglobulin isotype switching and secretion of IgE. (Ref.6) The agonistic 1C10 antibody closely resembles gp39/CD40 ligand in its ability to stimulate proliferation of small, resting B lymphocytes in the absence of other cofactors. (Ref.2)Synonyms: B-cell surface antigen CD40, Bp50, CD40L receptor, CDw40, TNFRSF5, Tumor necrosis factor receptor superfamily member 5
Gene ID 21939
UniProt P27512
Research Area Stem Cells, Hematopoietic Progenitors, Adaptive Immunity, CD Antigens, Surface Receptors of Immune Cells, Apoptosis/Necrosis, Inflammation, Cancer
Pathways NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Application Notes Flow Cytometry: < / 2 μg/10^6 cells. (Ref.2)
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer PBS containing 0.09 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Expiry Date 12 months
Supplier Images
Flow Cytometry (FACS) image for anti-CD40 antibody (CD40 Molecule, TNF Receptor Superfamily Member 5) (FITC) (ABIN370939) anti-CD40 Molecule, TNF Receptor Superfamily Member 5 (CD40) antibody (FITC)
Background publications Grandien, Brás, Martinez: "Acquisition of CD40 expression during murine B-cell differentiation." in: Scandinavian journal of immunology, Vol. 43, Issue 1, pp. 47-55, 1996 (PubMed).

Santos-Argumedo, Gordon, Heath, Howard: "Antibodies to murine CD40 protect normal and malignant B cells from induced growth arrest." in: Cellular immunology, Vol. 156, Issue 2, pp. 272-85, 1994 (PubMed).

Heath, Wu, Howard: "Monoclonal antibodies to murine CD40 define two distinct functional epitopes." in: European journal of immunology, Vol. 24, Issue 8, pp. 1828-34, 1994 (PubMed).

Hasbold, Johnson-Léger, Atkins, Clark, Klaus: "Properties of mouse CD40: cellular distribution of CD40 and B cell activation by monoclonal anti-mouse CD40 antibodies." in: European journal of immunology, Vol. 24, Issue 8, pp. 1835-42, 1994 (PubMed).

Clark, Ledbetter: "How B and T cells talk to each other." in: Nature, Vol. 367, Issue 6462, pp. 425-8, 1994 (PubMed).

Noelle, Ledbetter, Aruffo: "CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation." in: Immunology today, Vol. 13, Issue 11, pp. 431-3, 1993 (PubMed).